Engineering the cellular fluidic microenvironment

Our group works hard to make progress in both technology development and molecular cell biology, and our training objective is that each trainee develops an in-depth understanding of engineering principals and cell biology by the time they leave the lab. Broadly, our work is organized around 3 distinct but overlapping research thrusts: 

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Technology

3D Microfluidics

Perfusable blood and lymphatic vascular models for understanding fluid-structure interactions in the microvasculature.

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Mechanism

Endothelial cell adhesion

Understanding Notch family receptor signaling in mediating fluid stress sensing and cell-cell junction dynamics.

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Translation

Cardiovascular disease

Humanized disease models of rare, inherited vascular disease for drug screening and target identification.