PUBLICATIONS
2020
Kutys, M.L.*, Polacheck, W.J.*, Welch, M.K., Gagnon, K.A., Koorman, T., Kim, S., Li, L., McClatchey, A.I., Chen, C.S.
Nature Communications
(2020)11:337
DOI: 10.1038/s41467-020-17102-x
Microfluidics for the study of mechanotransduction.
Griffith, C.M.*, Huang, S.A.*, Cho, C., Khare, T.M., Rich, M., Lee, G., Ligler, F.S., Diekman, B.O., Polacheck, W.J.
Journal of Physics Part D: Applied Physics
53(22):224004.
Wang, W.Y., Lin, D., Jarman, E.H., Polacheck, W.J., Baker, B.M.
Lab on a Chip
20(6):1153-1166.
DOI: 10.1039/C9LC01170F
2019
Collective tumor cell migration in the presence of fibroblasts.
Waldeland, J.O., Polacheck, W.J., Evje, S.
Journal of Biomechanics
100:109568.
PMID: 31902609, DOI: 10.1016/j.jbiomech.2019.109568
Photodynamic therapy and the biophysics of the tumor microenvironment.
Sorrin, A.J., Ruhi, M.K., Ferlic, N., Karimnia, V., Polacheck, W.J., Celli, J.P., Huang, H.C., Rizvi, I.R.
Photochemistry and Photobiology
96(2), 232-259.
PMID: 31895481, DOI: 10.1111/php.13209
A bile duct-on-a-chip with organ-level functions.
Du, Y., Khandekar, G., Llewellyn, J., Polacheck, W.J., Chen, C.S., Wells, R.G.
Hepatology
71(4):1350-1363
PMID: 31465556, PMCID: PMC7048662, DOI: 10.1002/hep.30918
Microfabricated blood vessels for modeling the vascular transport barrier.
Polacheck, W.J., Kutys, M.L., Tefft, J.B., Chen, C.S.
Nature Protocols
14, 1425-1454.
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Featured on the cover.
2018
Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis.
Benhamouche, S., O’Loughlin, E., Liu, C., Polacheck, W.J., Fitament, J., El-Bardeesy, N., Chen, C.S., McClatchey, A.I.
Development
145(9), 1-11.
Chopra, A. Kutys, M.L., Zhang, K., Polacheck, W.J., Sheng, C., Eyckmans, J., Seidman, J.G., Seidman, C.E., Hinson, J.T., Chen, C.S.
Developmental Cell
44(1):87-96
2017
Polacheck, W.J., Kutys, M.L., Yang, J., Eyckmans, J.E., Wu, Y., Vasavada, H., Hirschi, K.K., and Chen, C.S.
Nature
552:258-262
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Reviewed in a Current Biology dispatch entitled Vascular Permeability: Flow-Mediated, Non-canonical Notch Signalling Promotes Barrier Integrity.
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Reviewed as a spotlight in Trends in Cell Biology entitled Notching a New Pathway in Vascular Flow Sensing.
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Highlighted in Science Signaling editor's choice - cell and molecular signaling.
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Highlighted in Faculty of 1000 - Cell Biology.
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Highlighted in The Wyss Institute press release.
Alimperti, S., Mirabella, T., Bajaj, V., Polacheck, W.J., Ward, D., Duffield, J.D., Assoian, R., Chen, C.S.
Proc. Nat. Acad. Sciences USA
2017, 114(33):8758-8763.
Matrix degradability controls multicellularity of 3D cell migration.
Trappmann, B., Baker, B.M., Polacheck, W.J., Choi, C.K., Burdick, J.A., Chen, C.S.
Nature Communications
2017, 8(1):371
A microfluidics assay to study invasion of human placental trophoblast cells.
Abbas, Y., Oefner, C.M., Polacheck, W.J., Gardner, L., Farrell, L., Sharkey, A., Kamm, R.D., Moffett, A., Oyen, M.L
J. R. Soc. Interface
2017, 14(13): 20170131.
McCurley, A., Alimperti, S., Campos-Bilderback, S.B., Sandoval, R.M., Calvino, J.E., Reynolds, T.L., Quigley, C., Mugford, J., Polacheck, W.J., Dovey, J., Marsh, G., Huang, A., Qian, F., Wienreb, P.H., Dolinski, B.M., Moore, S., Duffield, J.S., Chen, C.S., Molitoris, B.A., Violette, S.M., Crackower, M.A.
J. Am. Soc. Nephrol.
2017, 28(6):1741-1752.
Older
Measuring cell-generated forces: a guide to the available tools.
Polacheck, W.J. and Chen, C.S.
Nature Methods
2016, 13(5): 415-423.
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Hinson, J.T., Chopra, A.C., Nafissi, N., Polacheck, W.J., Benson, C.C., Swist, S., Gorham, J., Yang, L., Schafer, S., Hubner, N., Church, G., Cook, S.A., Linke, W.A., Chen, C.S., Seidman, J.G., Seidman, C.E.
Science
2015, 349 (6251): 982-986
Scarcelli, G., Polacheck, W.J., Nia, H.T., Grodzinsky, A.J., Kamm, R.D., Yun, S.H.
Nature Methods
2015, 12(12): 1132-1134
Mechanotransduction of fluid stresses governs 3D cell migration.
Polacheck, W.J., German, A.E., Mammoto, A., Ingber, D.E., and Kamm, R.D.
Proc. Nat. Acad. Sciences USA
2014, 111(7): 2447-2452
Probabilistic voxel-FE model for single cell motility in 3D.
Borau, C., Polacheck, W.J., Kamm, R.D., Garcia-Aznar, J.M.
In Silico Cell and Tissue Science
2014, 1 (1), 2
Polacheck, W.J. and Kamm, R.D.
J. Philosophy Science and Law
2014, 14:13-31
Microfluidic platforms for mechanobiology.
Polacheck, W.J., Li, R., Uzel, S.U., and Kamm, R.D.
Lab on a Chip
2013, 13(12):2252-2267
Tumor cell migration through complex microenvironments.
Polacheck, W.J., Zervantonakis, I.K., and Kamm, R.D.
Cell Mol. Life Sci.
2013, 70(8): 1335-1356
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Featured on the cover
Engineering of In Vitro 3D Capillary Beds by Self-Directed Angiogenic Sprouting.
Chan, J.M., Zervantonakis, I.K., Rimchala, T., Polacheck, W.J., Whisler, J., and Kamm, R.D.
PLoS ONE
2013, 7(12): e508
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Highlighted in Lab on a Chip
Interstitial flow influences tumor cell migration through competing mechanisms.
Polacheck, W.J., Charest, J.L., and Kamm, R.D.
Proc. Nat. Acad. Sciences USA
2011, 108(27): 11115-11120
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Highlighted on the MIT homepage
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Highlighted in the MIT Mechanical Engineering Newsletter
Stiffness of Photocrosslinked RGD-Alginate Gels Regulates Adipose Progenitor Cell Behavior.
Chandler, E.M., Berglund, C.M., Lee, J.S., Polacheck, W.J., Gleghorn, J.P., Kirby, B.J., and Fischbach, C.
Biotechnology and Bioengineering
2011, 108(7): 1683-1692
Methods for photocrosslinking alginate hydrogel scaffolds with high cell viability.
Rouillard, A.D., Berglund, C.M., Lee, J.Y., Polacheck, W.J., Tsui, Y., Bonassar, L.J., and Kirby, B.J.
Tissue Engineering
2010, 17(2): 173-179
Rouillard, A.D., Tsui, Y., Polacheck, W.J., Lee, J.Y., Bonassar, L.J., and Kirby, B.J.
Biomacromolecules
2010, 11(8): 2184-2189

